Binding of apoE-rich high density lipoprotein particles by saturable sites on human blood platelets inhibits agonist-induced platelet aggregation.
High density lipoproteins (HDL, d 1.063-1.21 g/ml) are reported to stimulate, to have no effect on, or to inhibit agonist-induced platelet aggregation.We have hypothesized that these conflicting reports might be explained by opposing effects of individual HDL subclasses on platelet aggregability.Physiologic concentrations of HDL3 had little effect